The timed trial is available as part of Xbox’s long-running Free Play Days promotion, which lets Game Pass subscribers try out the full versions of selected games each weekend at no additional charge.
Diablo 4 doesn’t require a Game Pass membership, but playtime is limited to 10 hours, Microsoft said.
Game Pass Core and Game Pass Ultimate members can also try out NBA 2K24, Lawn Mowing Simulator and Hokko Life this weekend.
Free Play Days kicked off on Thursday morning and is running until Sunday, October 22 at 11.59pm PT (October 23 at 2.59am ET / 7.59am BST).
It includes a new questline in which players recruit a vampire hunter voiced by actress Gemma Chan.
Xbox boss Phil Spencer said this week that players shouldn’t expect the company to start adding Activision Blizzard titles to Game Pass until 2024.